GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs2463822 | 1 | rs72921501 | chr11:62115622 | ASRGL1 | chr11:62104774-62160885:+ | -0.62 | -6.22 | 1.35E-8 | Chronic obstructive pulmonary disease-related biomarkers |
| THYM | cis | rs494003 | 1 | rs72922733 | chr11:65520746 | SNX32 | chr11:65601410-65621170:+ | 0.43 | 4.57 | 1.48E-5 | Systemic lupus erythematosus |
| THYM | cis | rs7301826 | 1 | rs7301826 | chr12:131291101 | STX2 | chr12:131274149-131323811:- | 0.35 | 5.89 | 5.79E-8 | Plasma plasminogen activator levels |
| THYM | cis | rs7303433 | 1 | rs7303433 | chr12:23640479 | SOX5 | chr12:23685232-24715380:- | -0.72 | -4.28 | 4.41E-5 | Schizophrenia |
| THYM | cis | rs9815354 | 1 | rs73069392 | chr3:41787009 | ULK4 | chr3:41288091-42003660:- | 1 | 10.33 | 3.31E-17 | Diastolic blood pressure |
| THYM | cis | rs9815354 | 1 | rs73069394 | chr3:41787233 | ULK4 | chr3:41288091-42003660:- | 0.99 | 11.02 | 1.12E-18 | Diastolic blood pressure |
| THYM | cis | rs9815354 | 1 | rs73069396 | chr3:41787236 | ULK4 | chr3:41288091-42003660:- | 0.99 | 11.02 | 1.12E-18 | Diastolic blood pressure |
| THYM | cis | rs9815354 | 1 | rs73071329 | chr3:41810539 | ULK4 | chr3:41288091-42003660:- | 1.01 | 10.74 | 4.29E-18 | Diastolic blood pressure |
| THYM | cis | rs9876781 | 1 | rs73074358 | chr3:48427247 | TREX1 | chr3:48501186-48509043:+ | -0.28 | -4.38 | 3.02E-5 | Longevity |
| THYM | cis | rs9815354 | 1 | rs73077367 | chr3:41851959 | ULK4 | chr3:41288091-42003660:- | 1 | 10.98 | 1.34E-18 | Diastolic blood pressure |
| THYM | cis | rs9815354 | 1 | rs73079316 | chr3:41863859 | ULK4 | chr3:41288091-42003660:- | 0.95 | 9.28 | 5.58E-15 | Diastolic blood pressure |
| THYM | cis | rs9815354 | 1 | rs73079321 | chr3:41863910 | ULK4 | chr3:41288091-42003660:- | 1 | 10.81 | 3.16E-18 | Diastolic blood pressure |
| THYM | cis | rs9815354 | 1 | rs73081353 | chr3:41906448 | ULK4 | chr3:41288091-42003660:- | 0.95 | 9.28 | 5.58E-15 | Diastolic blood pressure |
| THYM | cis | rs9815354 | 1 | rs73081364 | chr3:41913616 | ULK4 | chr3:41288091-42003660:- | 0.95 | 9.28 | 5.58E-15 | Diastolic blood pressure |
| THYM | cis | rs757978 | 1 | rs73116394 | chr2:242367915 | SEPT2 | chr2:242254723-242293439:+ | 0.44 | 6.02 | 3.32E-8 | Chronic lymphocytic leukemia |